• Get an antibody specific to your cell type. Or use anything that binds to a cell surface molecule and is internalized.
• Use a potent cytotoxin. Safe in the lab. Lethal in the cell.
• Advanced Targeting Systems puts them together to make a powerful targeting agent.
• The conjugate seeks out target markers on the cell surface.
• Once attached to its target receptor, the saporin conjugate is internalized. Cells which do not have the target receptor will not be affected.
• The SAPORIN conjugate enters the cell.
• The bond between SAPORIN and the targeting agent is broken in the endosome.
• Saporin inactivates the ribosome resulting in cell death.

Home | Tutorial | Catalog | News | References | Search | Contact | Site Map
ADVANCED TARGETING SYSTEMS